Introduction

In the pathogenesis of the diabetes once the free radi -cals were implicated, in the sick persons with diabetes, the atherosclerosis it has between characteristic others to be precocious, accelerated, severe and extensive, at this moment has influence to a large extent the secondary dislipoproteinemia to the hyper-glucemia, the lipoproteín’s glucosilation produce changes in them same, that more aterogenics make them and, besides, generate free radicles that provoke oxidation of the ap -oprotein of the lipids in the cellular core and of close macromolecules [1,2,3].

The appearing of Diabetes mellitus ( DM ) in the ten -der age of life, represent a serious situation for what’s difficult that is to maintain under good control these patients and for the frequent development of compli -cations several years after initiate the disease. For it, it is necessary to accomplish a precocious, forceful and efficacious treatment to avoid or to postpone the pres -ence of those complications, to teach a new style of life to those patients and to improve the prognosis and the living conditions of the same [4,5,6].

The free radicals are implicated not only in her the diabetic’s complications, but also with the etiology of diabetes [7,8].

For it before exposed we proposed ourselves: Evaluat -ing the antirust effects of vitamin And in children with Diabetes mellitus type1.

Materials and Methods

A study in 30 patients that attend the consultation of endocrinology of the Pediatric Provincial Teaching Hospital came true. Dr. Eduardo Agramonte Piña of Camaguey in the period of August to November of 2012.

Criteria of inclusion

Ambulatory patients with the diagnosis of diabetes mellitus type 1, with ages between 5-16 years and with over three years of evolution of the disease.

Criteria of exclusion

Patients hospitalized by decompensation of the disease.

Patients with associated to pathologies diabetes mellitus.

Patients that consume medications that get in the way in the levels of lipids and or antioxidant biological to determine.

Low consent informed they took of the parents like note of the approval that the little boy will participate in investigation you show of blood for the multilevel determination of total cholesterol (enzymatic method ), Triglicerides (enzymatic method), LDL cholester -ol, HDL cholesterol (enzymatic method), uric acid ( chemical Method with 2,4 dinitrofenilhidrazin), vita -min C ( Gendrasik Grof), bilirrubin (modified Ravin), glucemia (Rapiglucotest), ceruloplasmin (enzymatic method) albumin (green bromocresol), and like marker of oxidative stress levels of LDL rusted determined themselves enzymatic method with Precipitation with PEG 6000 ).

The determinations of lipids, seric antioxidants admin -istrated Vitamin E pills (400 daily mg), during three months, coming true themselves, and LDL rusted in each month, in order to demonstrate the presence and correction of the oxidative stress, the results obtained before compared and after the antioxidant therapy.

Data were processed by means of descriptive statistics, with absolute and relative frequency distribution, coming true a hypothesis testing for matching observations in each complementary accomplished.

Results

They showed up before the treatment once the levels of vitamin were decreased C (33 %), ceruloplasmin (17 %) and albumin (63 %). One of the antioxidant determined decreasedly showed up at least in the patients’ totality.

The decrease of the antirust stock triggers free radicals’ accumulation, for its part, you perform on the uric acid like antirust together with the vitamin C, the first one possesses a couple of electrons shared in that you perceive the reactive sorts of oxygen and it gives them up to the vitamin C, creating for oneself an innocuous complex that is eliminated easily at the organism, when you find the levels of one of them decreasedly the unbalance becomes established.

As to the profile lipidic triglycerides (13 %), the total cholesterol (50 %) and the LDLox detected incremented levels themselves than the principal marker of oxidative stress in 100 % of the patients.

Studies accomplished at the pediatric provincial teach -ing hospital’s Clinical Laboratory Eduardo Agramonte Pina they have demonstrated than the sensibility of the LDL to oxidation the associate to the hiperlipemia is not, but to the degree of oxidative stress, which is able to unbalance the disease.

The numbers of glucemia found in 93 % of the patients lifted without yielding criteria of hospitalization, therefore it came to an end than the same they pre -sented a bad metabolic control of the disease, which is attributed to in what’s fundamental the diet.

When concluding the pharmacologic treatment could appreciate to to him an increment in the seric levels of the antirust determined, the levels of lipids like the total cholesterol and the LDL-C the equals, the HDL maintained C themselves it increased lightly and the rusted LDL decreased significantly, this suggests a decrease of lipoperoxide’s levels and for there a bigger protection in front of the oxidative damage of the li -pids, with which may prevent him or delaying the possible complications of Diabetes mellitus in whose etiology the oxidative stress implicates itself.

×

Table1:

Close

Table 1: Half a levels of antioxidant and seric lipids in the patient elks and during the treatment with Vitamina.

Conclusions

Exists an oxidative stress in the children affected by diabetes mellitus type 1 for 76 % of diagnosed patients.

The diet demonstrated a bad metabolic control of the associated to disease itself in 100 % of the patients.

In the diabetic children with 400 daily mg of Vitamin E And during 3 months was able to correct the oxidative stress.

Recommendations

Including of diabetes mellitus type 1 to the pharmacologic treatment with vitamin E and to correct the stress oxidativo.

Insisting on the metabolic control of the dis -ease, on the basis of achieving a balanced diet.