Marginal Adaptability of Custom Made Cast Post Made by Different Techniques - A Literature Review
Pranati T1, Manish Ranjan2*, Hima Sandeep A3
1 Undergraduate Student Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
2 Associate Professor, Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
3 Senior Lecturer, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
*Corresponding Author
Dr. Manish Ranjan,
Associate Professor, Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha
University, Chennai 600077, Tamil Nadu, India.
Tel: +91- 9543445029
E-mail: manish@saveetha.com
Received: May 20, 2021; Accepted: August 11, 2021; Published: August 18, 2021
Citation:Pranati T, Manish Ranjan, Hima Sandeep A. Marginal Adaptability of Custom Made Cast Post Made by Different Techniques - A Literature Review. Int J Dentistry Oral Sci. 2021;8(8):3954-3959. doi: dx.doi.org/10.19070/2377-8075-21000809
Copyright: Dr. Manish Ranjan©2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction: A post and core is a type of dental restoration required where there is an inadequate amount of sound tooth
tissue remaining to retain a conventional crown.Marginal and internal adaptation of indirect restorations are both very important
parameters that may affect the periodontal status and longevity of the restorations. .In this review we report all the factors
responsible for affecting the marginal adaptability of post and core systems used in restoration of endodontically treated teeth.
Purpose: To find out all those factors which can be used to increase marginal adaptability which ultimately enhance the clinical
success rate. Since Increased marginal discrepancies of post endodontic restorations are related to increased exposure of
the luting material to the oral environment, leading to chemo-mechanical degradation of the cement and the adhesive interface
between the tooth structure, luting agent, and esthetic indirect restoration.
Conclusion: The performance of a CAD-CAM system relative to marginal adaptation is influenced by the restorative material.
Digital workflow has several advantages over conventional casting, such as eliminating the need for impression material
and transportation, reducing the time-consuming laboratory procedures, increasing patient comfort and the marginal adaptability
and internal fit.
2.Introduction
3.Conclusion
4.References
Keywords
CAD-CAM; Cast Metal; Custom Post; Microleakage; Zirconia.
Introduction
After root canal treatment, dentists are subjected with the task of
restoring the tooth to rehabilitate oral functions as well as aesthetics.
A post and core crown is a type of dental restoration required
where there is an inadequate amount of sound tooth tissue remaining
to retain a conventional crown [1]. A post is cemented
into a prepared root canal, which retains a core restoration, which
retains the final crown. The role of the post is firstly to retain a
core restoration and crown, and secondly to redistribute stresses
down onto the root, thereby reducing the risk of coronal fracture.
The post does not play any role in reinforcing or supporting the
tooth and can in fact make it more likely to fracture at the root.
The restoration must achieve adequate retention and circumvent
damage to the remaining hard tissue through the prevention of
bacterial microleakage and hard-tissue fractures. Studies indicate
that the tooth is less prone to fracture when less dental hard tissue
is removed during the process of treatment. On the other
hand, endodontic therapy is often necessitated by pulpal infection
after substantial hard-tissue loss by caries or following extensive
tooth preparation for crown- and bridgework. In both
cases, much hard tissue has already been lost before root canal
therapy. Therefore, there is often insufficient dental hard tissue
left to ensure adequate retention of a functional restoration after
endodontic treatment without adjuvant aids [2]. It was considered
that a post with an ideal length of two-third of the total root
length would reinforce the compromised tooth [3]. The length
of the post is less important for the survival of the tooth than
the presence of a ferrule of at least 1.5 mm. Materials with a
high modulus of elasticity, like cast gold alloys [90 GPa], stainless steel [170 GPa], or titanium [115 GPa] were favored and, as an
esthetic alternative, zirconium posts [200 GPa] were introduced.
Stainless steel and titanium posts were mainly used with plastic
core materials, like composite and amalgam. Gold posts and ceramic
posts were used either with plastic core materials or with
indirect cast gold or pressed ceramic cores, respectively. [4] About
10 years ago, glass, polyethylene, quartz, or carbon-reinforced
composites [20–30 GPa] with a lower, more dentinlike [18 GPa]
modulus of elasticity were introduced to dentistry. These fiberreinforced
posts fulfill the requirements of dentists who prefer to
use prefabricated posts and resin-based composite core buildups.
[5] The advantages of this direct post-and core technique include
lower costs due to the exclusion of the dental technician, one less
appointment, and the preclusion of unnecessary temporization.
[4] The optimal modulus of elasticity of a post is controversial.
Stiffer posts and cores may better support the coronal restoration
and lead to a more uniform distribution of stress, but may result
in catastrophic failure modes, like vertical root fractures, if the
tooth is overloaded. A more elastic post may bend under high
loads, which may lead to failure or loss of the restoration, but
would leave the root intact for retreatment. On the other hand, an
elastic post may allow the restoration to move and thus leak, after
breakdown of the luting cement, with coronal leakage that puts
the tooth at risk of secondary caries or root canal reinfection [6].
A well-adapted, passively cemented parallel-sided post is considered
to be the most retentive with the least stress. However, with
a flared canal, the parallel-sided post does not closely approximate
the canal wall in the cervical region of the root. In such a
situation, the clinician must decide whether to use a parallel-sided
post and fill the space with cement or use a tapered post that
closely adapts to the prepared canal. Maximum adaptation of the
tapered post to the residual root structure significantly increases
the fracture resistance of the endodontically treated tooth, but the
tapered post results in an extensive and higher incidence of root
fracture [1].
Marginal and internal adaptation of indirect restorations are both
very important parameters that may affect the periodontal status
and longevity of the restorations. Marginal gap is defined as “the
perpendicular measurement from the internal surface of the casting
to the axial wall of the preparation at the margin”[7]. Gap
measurements at the margin of restorations are frequently used
to quantify fit [8]. Increased marginal discrepancies are related to
increased exposure of the luting material to the oral environment,
leading to chemo-mechanical degradation of the cement and the
adhesive interface between the tooth structure, luting agent, and
esthetic indirect restoration. Internal fit is another key factor related
to the long-term stability of esthetic indirect restorations.
The cement interface has been described as a crack initiation area.
Increased interfacial space and resin cement thickness may create
increased polymerization shrinkage and interfacial stresses,
resulting in decreased strength of the tooth-restoration interface.
A sufficient three-dimensional [3D] fit of the restoration has been
considered mandatory to obtain maximum mechanical support
of all-ceramic restorations from the tooth structure. [9] A study
by Iglesias et al showed that marginal gaps ranged from 7 to 23
microns and that resin patterns had statistically smaller gaps than
inlay wax patterns. Studies have shown that there is a wide range
of acceptable values for the upper limit [50 to 150 microns] of
a clinically acceptable marginal gap [8]. At this time, there is no
clinical evidence for a minimally acceptable marginal gap, however,
acceptable marginal discrepancies of inlays are 20 microns
at the occlusal surface and 74 microns at the gingival margin have
been reported [10]. The material used in the technique is inlay
wax. The advantages of this technique include the precise fit of
the post into the post space along with less chairside time, as the
wax pattern is not fabricated inside the patient's mouth.If the selected
post closely fits or conforms to the canal shape and size , it
may be a more conservative option because less dentin removal is
required, thus enhancing fracture resistance of the tooth, as well
as retention of the post [11].
The cast all-ceramic and especially the cast metal post-and-core
systems with a high modulus of elasticity exhibited better and
more stress-resistant marginal adaptation at the tooth-to-luting
composite interface than the endo-crown or the glass-fiber-postsupported
crown. The reason might be that the deformation of
the root was limited by the stiff post-and-core systems, whereas
the composite resin crown was proportionally more deformed
than the root, leading to a slightly increased loss of marginal integrity
at the luting composite-to-crown interface [4].
Previously our team has a rich experience in working on various
research projects across multiple disciplines [12-26]. Now the
growing trend in this area motivated us to pursue this project.
In this review we report all the factors responsible for affecting
the marginal adaptability of post and core systems used in restoration
of endodontically treated teeth.
Factors Affecting the Marginal Adaptability
1) Types Of Post
- Prefabricated Post
- Custom Made Cast Post
2) Design Of Post
- Parallel Post
- Tapered Post
3) Material Used For Fabrication Of Post
- Cast Metal Alloy
- Base Metal Alloy
- Zirconia
- Peek
4) Methods Used For Fabrication Of Post
- Direct Technique
- Indirect Techniques
- Lost Wax Technique
- Resin Pattern
5) Impression Techniques
6) Fabrication Method
- Casting Methods
- Cad Cam
- 3D Additive Manufacturing
Adaptation of a tapered post to a prepared canal can determine
the clinical survival rate of a damaged tooth [27, 28]. The close
contact between the walls of the root canal can determine the
clinical survival rate of a damaged tooth. The close contact between
the root canal wall and the post is necessary to achieve the
passivity of fit and good marginal adaptation [29]. Moreover, it
has been shown that uniform cement with minimum thickness
will result in high adaptation and bond strength of posts, [30] which in turn dissipates the imposed stress from the post equally
throughout the canal [31]. Increased cement space due to the application
of a non adapted post system will significantly affect the
retention of the posts [32].
Types Of Post
Prefabricated Post: Combined fiber/zirconia prefabricated
posts present a good alternative for restoration with posts and
cores. In one of the studies, the mean load failure values for these
posts were significantly greater in comparison with all the other
post-and-core systems evaluated. However, it should be considered
that prefabricated fiber posts have a predetermined diameter
that may be too wide for some canals, especially for mandibular
incisors. Also in non circular canals, a prefabricated post may be
contraindicated because of poor adaptation of the post to the
canal [33].
Custom Made Cast Post: High adaptation of the post to the
root canal would result in a thinner cement layer. This thinner
cement layer would lead to higher wettability, bond strength between
the post and the dentin. Also, it would generate less tensile
stress at the adhesive dentin interface due to its lower polymerization
shrinkage stress and would have few defects to cause a
cohesive fracture. Su et al. found that the CAD/CAM produced
one-piece glass fiber post-and core had an excellent adaptation to
the root canal in comparison with conventional fiber posts [34]. It
was also able to achieve strong bonding properties in the canal to
prevent dislodgement by minimizing the cement thickness. These
features made the CAD/CAM glass fiber post-and core especially
suitable in restoring the flared roots or defected teeth with incomplete
ferrule [34, 35].
Design Of Post
In addition to the custom cast post and core, many commercially
available pre- fabricated posts exist. For example, the axial form is
either tapered or parallel, and the surface can be smooth, serrated
with or without vents, or threaded using taps or self-threading.
Caputo and Standlee categorize these different design features
into three basic combinations:
1) Tapered, serrated or smooth- sided, cemented into a post space
prepared with a matched-size post drill;
2) Parallel-sided, serrated or smooth-sided, cemented into
matched cylindrical channels prepared by a post drill;
3) Parallel-sided, threaded and inserted into pre- tapped channels.
[36].
In general, parallel-sided posts are more retentive than tapered
posts, and threaded posts are more retentive than cemented posts.
With respect to their installation mode, all posts are referred to
as either active or passive. Active posts engage dentin within the
root canal space and transfer more stress to the remaining root
structure. Passive posts, even though they do not engage dentin
in the root canal space, still transfer stress to the remaining root
structure, but to a lesser extent [37].
Material Used For Fabrication Of Post
Cast Metal Alloy: Advantages of cast post and cores include
their high strength, durability, and the strong union between the
core and the post. However, cast posts and cores have been associated
with more unfavorable deep root fractures, perhaps because
of their relatively high modulus of elasticity. Cast post and cores
can also offer an advantage over other post systems for teeth with
extensive tooth damage, partial fixed dental prosthesis abutments,
and bruxism and other heavy occlusion situations [38].
After ageing, the titanium system showed the highest marginal
gap [14%] at the cement-crown interface. At the cement-tooth
interface the restorations with titanium posts showed the least
marginal deterioration after ageing, followed by the fibre-reinforcement
system and the system without post [39].
The success rates reported by Sorensen and Martinoff are not in
agreement with three in vivo studies. [40] Bergman et al recorded
a success rate of more than 90% in a retrospective study of 96
teeth treated with cast posts and cores, and they concluded that
the traditional custom cast post and core can be recommended.
[41] Weine et al .reported a failure rate of only 6.5% after more
than 10 years for 138 teeth treated with tapered smooth cast posts
developed from plastic burnout patterns. [42] Hatzikyriakos et al
examined 154 post and core restorations for a 3-year period and
noted a 94.5 % success rate for single crowns restored with three
different post systems: screw posts, parallel-sided serrated posts,
and cast metal posts. A failure rate of 16.4% was recorded for
pulpless teeth serving as abutments to fixed partial dentures, and
abutments to removable partial dentures also had a higher failure
rate than single crowns. Nevertheless the type of post did not
influence the success rate [43]. Additional compar- isons of the
failure rate of teeth restored with cast posts that closely reflect
traditional treatment advocated by contemporary texts might be
more informative.
Zirconia: The evolution of nonmetal post systems, including fiber-
reinforced resin posts, has led to improved esthetics and more
favorable stress distribution patterns [44].
Ageing caused an increase of marginal gap to 7% for Cera post
restorations and to 8% for the Vectris system. It was remarkable
that the application of the brittle ceramic system, using the post
with highest Young’s modulus, decreased the marginal adaptation
by about 10% with the same interface. These results indicate that
the flexibility of post and bonding within the range of human
dentine helps distribute low mastication forces evenly within the
restorative system . In contrast, we suppose that a stiff post transfers
force peaks to the weakest point of the restoration – generally
the bonding between cement and tooth. [39].
The cast all-ceramic and especially the cast metal post-and-core
systems with a high modulus of elasticity exhibited better and
more stress-resistant marginal adaptation at the tooth-to-luting
composite interface than the endocrown or the glass-fiber-postsupported
crown. The reason might be that the deformation of
the root was limited by the stiff post-and-core systems, whereas
the composite resin crown was proportionally more deformed
than the root, leading to a slightly increased loss of marginal integrity
at the luting- composite-to-crown interface [4].
The results of the study indicate that 1-piece milled zirconia posts
and cores behaved similarly, without a statistically significant difference,
compared to cast posts and cores, offering an acceptable alternative for restorations of anterior teeth with high esthetic demands
and when a custom post and core is required [45].
There was a significant difference in marginal gap distance when
comparing 1-piece milled zirconia posts and cores versus the
acrylic resin patterns. After adjustments, the posts fit passively
into the canal and did not bind, as no pressure spots were observed
when using a silicone disclosing agent. However, the posts
were not fitting accurately, probably due to dimensional changes.
Regardless, the load values in both the pilot study and definitive
study resulted in similar load values between the 1-piece milled
zirconia posts and cores and cast gold post and cores [33].
PEEK [ Poly ethyl ether ketone]: PEEK material is also being
used as a post and core system. In one of the study the push
out bond strength for modified PEEK post in the apical region
[7.593 ± 1.422] was found to be highest followed by middle region
[6.279 ± 1.088] and least in the coronal region [6.178 ±
1.048]. The mean push-out bond strength for glass fiber post in
the coronal region was found to be significantly higher than that
of the modified PEEK post and the difference was found to be
statistically significant. The mean push-out bond strength of the
glass fiber post in the middle region was found to be significantly
higher than that of the modified PEEK post and the difference
was found to be statistically significant. The mean push-out bond
strength for glass fiber post in the apical region was found to be
significantly higher than that of the modified PEEK post and the
difference was found to be statistically insignificant [46].
Methods Used For Fabrication Of Post
Marginal adaptability of post and core also depends on the method
of fabrication of post and core. According to one of the study,
the overall space between the canal walls and posts made with
the direct technique ranged between 7.86 and 17.39 mm3, with a
mean value of 12.25 mm3, whereas with the indirect technique,
the space ranged between 6.68 and 18.02 mm3, with a mean of
11.92 mm3.Although most dental prostheses are fabricated indirectly
in the dental laboratory, which is more convenient for both
the dentist and the patient, many practitioners prefer the direct
technique for post pattern fabrication because they assume it provides
a more accurate fit. [47].
All cast metal posts were shorter than the impressions. The mean
reduction for the metal posts was 2.3% for direct in anterior
teeth, 5.7% for direct in posterior teeth, 6.3% for indirect in anterior
teeth, and 7.2% for indirect in posterior teeth [all P<.05].
Statistically significant differences were found between time of
technique and tooth position [P=.031], with the direct technique
more time consuming than the indirect technique [P<.001] for
both tooth positions. For the indirect technique, the impression
times for both tooth groups were similar [P=.459][48].
The major advantages of cast posts are low cost, no clinical technique
or special cement for fixation, a long history of clinical use,
and excellent radiopacity. However, the result of dental lost-wax
casting techniques is greatly influenced by the inherent properties
of the dental materials, such as the expansion and contraction of
all materials used, including impression materials, waxes, gypsum
products, plastics, and metals.Distortions in the casting process
result in a nonuniform pre- cementation space and absence of
passivity and fitting between tooth and metal and inadequate endodontic
healing [49].
A few studies have compared the accuracy of the cast metal posts
considering impression techniques and tooth position. The indirect
technique with polyvinyl siloxane impression material has
been found to reproduce the details of the root canal space is
faster and easier than the direct technique, especially when multiple
posterior teeth are involved or when shorter clinical chair time
is necessary; yet the direct technique is reliable and has several advantages,
including easy manipulation of acrylic resin, dimensional
stability, easy adjustment in the mouth when needed, and less
working time at the laboratory, albeit with longer clinical time [50]
Although we found differences between the replicated post space
and cast post lengths, they were considered clinically irrelevant,
with a mean reduction of 2.3% [0.3 mm] for direct in anterior
teeth, 5.7% [0.7 mm] for direct in posterior teeth, 6.3% [0.6 mm]
for indirect in anterior teeth, and 7.2% [0.7 mm] for indirect in
posterior teeth. These results showed that metal posts fabricated
with the direct technique presented fewer differences between
impressed post space and cast posts but without any statistically
significant difference. The indirect technique presented a higher
percentage of shortage, probably because the dental technician
creates a relief in the gypsum cast on which the acrylic resin pattern
is made; this results in a greater probability of inaccuracy in
the cast. Seating interferences from the resin patterns in the dental
laboratory often occur with the indirect technique and are probably
linked to ability of the technician and the inherent distortions
of the materials used with the indirect technique [47].
CAD CAM Designed Post And Core
Nowadays, CAD/CAM technology can facilitate the fabrication
of different dental prostheses, ranging from a single crown to
complex fixed and removable dental restorations. Since the accuracy
of the digital workflow seems to be the same as conventional
systems, CAD/CAM technology has been used for post-and-core
fabrication as well. Digital workflow has several advantages over
conventional casting, such as eliminating the need for impression
material and transportation, reducing the time-consuming laboratory
procedures, and increasing patient comfort. [51-54]. Until
recently, scanning the intra-canal space was not possible in most
cases because of the anatomy of the canal. However, 3Shape
has developed special scan posts to improve accuracy [55]. The
full-digital dual-scan workflow using 3Shape scan posts has been
claimed to accurately record the exact depth and anatomy of the
root canal. This method makes it possible to design all layers of
a post and core in a single digital work-flow. The available commercial
scan posts have a circular shape [54]. With the application
of digital technology, posts and Cores can be designed and
manufactured in a single Laboratory session, which is convenient
and time-saving, Especially in patients needing multi-unit restorations.
Therefore, a digital workflow eliminates the complications
of conventional casting, such as choosing a tray, Preparation of
the impression materials, disinfection of The impressions, and
transferring the impression to the Laboratory [56, 57]. Nevertheless,
digital workflow should meet a criteria to be used in clinical
settings. A 10-year retrospective study concluded that adequate
Post adaptation dramatically increases tooth survival rate [58]. Active
fit of a post and a non-homogeneous Cement layer might
exert off-axis stress on the tooth Structure and increase the stress
peaks, which in turn Increase the fracture risk of the restored teeth.[27, 29]. The cast posts had less apical gap compared to the
milled posts. Cast posts conform better to irregularities and Fit
perfectly with the canal, which is evident from their Long history
of success in clinical settings. Among the Milled posts, as it was
anticipated, the round canals resulted in less apical gap than the
oval canals, as the scan Posts could reach further into the round
canals. 2-mm apical gap is an acceptable clinical cut-off point,
below which dislodgement and fracture may occur [59].
Our institution is passionate about high quality evidence based
research and has excelled in various fields [16],[60-69].
Conclusion
The restoration of endodontically treated teeth with the use of
custom made cast post-core material displayed promising performance
in matter of microgap and load-bearing capacity.Most of
the CAD-CAM restorations/infrastructures were within the clinically
acceptable marginal discrepancy range. The performance of
a CAD-CAM system relative to marginal adaptation is influenced
by the restorative material. Digital workflow has several advantages
over conventional casting, such as eliminating the need for
impression material and transportation, reducing the time-consuming
laboratory procedures, and increasing patient comfort.
More clinical and in vitro studies are required to drawn conclusion
relative to marginal adaptation about the superiority of CAD
CAM milling technology as opposed to the DMLS processes.
References
-
[1]. Govindaraju L, Gurunathan D. Effectiveness of Chewable Tooth Brush
in Children-A Prospective Clinical Study. J Clin Diagn Res. 2017
Mar;11(3):ZC31-ZC34.Pubmed PMID: 28511505.
[2]. Christabel A, Anantanarayanan P, Subash P, Soh CL, Ramanathan M, Muthusekhar MR, et al. Comparison of pterygomaxillary dysjunction with tuberosity separation in isolated Le Fort I osteotomies: a prospective, multi-centre, triple-blind, randomized controlled trial. Int J Oral Maxillofac Surg. 2016 Feb;45(2):180-5.Pubmed PMID: 26338075.
[3]. Soh CL, Narayanan V. Quality of life assessment in patients with dentofacial deformity undergoing orthognathic surgery--a systematic review. Int J Oral Maxillofac Surg. 2013 Aug;42(8):974-80.Pubmed PMID: 23702370.
[4]. Mehta M, Deeksha, Tewari D, Gupta G, Awasthi R, Singh H, et al. Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases. Chem Biol Interact. 2019 Aug 1;308:206- 215.Pubmed PMID: 31136735.
[5]. Ezhilarasan D, Apoorva VS, Ashok Vardhan N. Syzygium cumini extract induced reactive oxygen species-mediated apoptosis in human oral squamous carcinoma cells. J Oral Pathol Med. 2019 Feb;48(2):115-121.Pubmed PMID: 30451321.
[6]. Campeau PM, Kasperaviciute D, Lu JT, Burrage LC, Kim C, Hori M, et al. The genetic basis of DOORS syndrome: an exome-sequencing study. Lancet Neurol. 2014 Jan;13(1):44-58.Pubmed PMID: 24291220.
[7]. Sneha S. Knowledge and awareness regarding antibiotic prophylaxis for infective endocarditis among undergraduate dental students. Asian J Pharm Clin Res. 2016 Oct 1:154-9.
[8]. Christabel SL, Linda Christabel S. Prevalence of type of frenal attachment and morphology of frenum in children, Chennai, Tamil Nadu. World J Dent. 2015 Oct;6(4):203-7.
[9]. Kumar S, Rahman R. Knowledge, awareness, and practices regarding biomedical waste management among undergraduate dental students. Asian J Pharm Clin Res. 2017;10(8):341.
[10]. Sridharan G, Ramani P, Patankar S. Serum metabolomics in oral leukoplakia and oral squamous cell carcinoma. J Cancer Res Ther. 2017 Jul 1;13(3):556- 561.
[11]. Ramesh A, Varghese SS, Doraiswamy JN, Malaiappan S. Herbs as an antioxidant arsenal for periodontal diseases. J Intercult Ethnopharmacol. 2016 Jan 27;5(1):92-6.Pubmed PMID: 27069730.
[12]. Thamaraiselvan M, Elavarasu S, Thangakumaran S, Gadagi JS, Arthie T. Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession. J Indian Soc Periodontol. 2015 Jan;19(1):66-71.
[13]. Thangaraj SV, Shyamsundar V, Krishnamurthy A, Ramani P, Ganesan K, Muthuswami M, et al. Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations. PLoS One. 2016 Jun 9;11(6):e0156582.Pubmed PMID: 27280700.
[14]. Ponnulakshmi R, Shyamaladevi B, Vijayalakshmi P, Selvaraj J. In silico and in vivo analysis to identify the antidiabetic activity of beta sitosterol in adipose tissue of high fat diet and sucrose induced type-2 diabetic experimental rats. Toxicol Mech Methods. 2019 May;29(4):276-290.Pubmed PMID: 30461321.
[15]. Ramakrishnan M, Shukri M. Fluoride, Fluoridated Toothpaste Efficacy And Its Safety In Children-Review. Int J Pharm Res. 2018 Oct 1;10(04):109-14.
[16]. Vârlan C, Dimitriu B, Vârlan V, Bodnar D, Suciu I. Current opinions concerning the restoration of endodontically treated teeth: basic principles. J Med Life. 2009 Apr-Jun;2(2):165-72.Pubmed PMID: 20108535.
[17]. Goodacre CJ, Spolnik KJ. The prosthodontic management of endodontically treated teeth: a literature review. Part I. Success and failure data, treatment concepts. J. Prosthodont. 1994 Dec;3(4):243-50.
[18]. Libonati A, Di Taranto V, Gallusi G, Montemurro E, Campanella V. CAD/ CAM Customized Glass Fiber Post and Core With Digital Intraoral Impression: A Case Report. Clin Cosmet Investig Dent. 2020 Feb 10;12:17-24. Pubmed PMID: 32104100.
[19]. Bilgin MS, Erdem A, Dilber E, Ersoy I. Comparison of fracture resistance between cast, CAD/CAM milling, and direct metal laser sintering metal post systems. J Prosthodont Res. 2016 Jan;60(1):23-8.Pubmed PMID: 26347450.
[20]. Tamac E, Toksavul S, Toman M. Clinical marginal and internal adaptation of CAD/CAM milling, laser sintering, and cast metal ceramic crowns. J Prosthet Dent. 2014 Oct 1;112(4):909-13. [21]. Prabhu R, Prabhu G, Baskaran E, Arumugam EM. Clinical acceptability of metal-ceramic fixed partial dental prosthesis fabricated with direct metal laser sintering technique-5 year follow-up. J Indian Prosthodont Soc. 2016 Apr-Jun;16(2):193-7.Pubmed PMID: 27141171.
[22]. Vijayashree Priyadharsini J. In silico validation of the non-antibiotic drugs acetaminophen and ibuprofen as antibacterial agents against red complex pathogens. J Periodontol. 2019 Dec;90(12):1441-1448.Pubmed PMID: 31257588.
[23]. Pc J, Marimuthu T, Devadoss P, Kumar SM. Prevalence and measurement of anterior loop of the mandibular canal using CBCT: A cross sectional study. Clin. Implant Dent. Relat. Res. 2018 Apr 6;20(4):531-4.
[24]. Ramesh A, Varghese S, Jayakumar ND, Malaiappan S. Comparative estimation of sulfiredoxin levels between chronic periodontitis and healthy patients - A case-control study. J Periodontol. 2018 Oct;89(10):1241-1248.Pubmed PMID: 30044495.
[25]. Ramadurai N, Gurunathan D, Samuel AV, Subramanian E, Rodrigues SJ. Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial Clin Oral Investig. 2019 Sep;23(9):3543-50.
[26]. Sridharan G, Ramani P, Patankar S, Vijayaraghavan R. Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma J Oral Pathol Med. 2019 Apr;48(4):299-306.
[27]. Mathew MG, Samuel SR, Soni AJ, Roopa KB. Evaluation of adhesion of Streptococcus mutans, plaque accumulation on zirconia and stainless steel crowns, and surrounding gingival inflammation in primary molars: randomized controlled trial. Clin Oral Investig. 2020 Sep;24(9):1-6.Pubmed PMID: 31955271.
[28]. Samuel SR. Can 5-year-olds sensibly self-report the impact of developmental enamel defects on their quality of life? Int J Paediatr Dent. 2021 Mar;31(2):285-286.Pubmed PMID: 32416620.
[29]. R H, Ramani P, Ramanathan A, R JM, S G, Ramasubramanian A, et al. CYP2 C9 polymorphism among patients with oral squamous cell carcinoma and its role in altering the metabolism of benzo[a]pyrene. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Sep;130(3):306-312.Pubmed PMID: 32773350.
[30]. Chandrasekar R, Chandrasekhar S, Sundari KKS, Ravi P. Development and validation of a formula for objective assessment of cervical vertebral bone age. Prog Orthod. 2020 Oct 12;21(1):38.Pubmed PMID: 33043408.
[31]. Vijayashree Priyadharsini J, Smiline Girija AS, Paramasivam A. In silico analysis of virulence genes in an emerging dental pathogen A. baumannii and related species. Arch Oral Biol. 2018 Oct;94:93-98.Pubmed PMID: 30015217.
[32]. Schwartz RS, Robbins JW. Post placement and restoration of endodontically treated teeth: a literature review. J. Endod. 2004 May 1;30(5):289-301. [33]. Terry DA, Swift EJ. Post-and-cores: past to present. Dent Today. 2010 Jan;29(1):132, 134-5.Pubmed PMID: 20084862.
[34]. Sriram S, Shankari V, Chacko Y. Computer aided designing/computer aided manufacturing in dentistry (CAD/CAM)–A Review. Int J of Cur Res Rev. 2018 Oct 26;10(20):20-4.
[35]. Beck N, Graef F, Wichmann M, Karl M. In vitro fracture resistance of copymilled zirconia ceramic posts. J Prosthet Dent. 2010 Jan;103(1):40-4.Pubmed PMID: 20105682.
[36]. Rosentritt M, Fürer C, Behr M, Lang R, Handel G. Comparison of in vitro fracture strength of metallic and tooth-coloured posts and cores. J. Oral Rehabil. 2000 Jul;27(7):595-601.
[37]. Estaki Z, Afshar H, Ghadimi S, Derakhshan S. Effect of Layering Technique on Push-Out Bond Strength of Composite Resin to Intracanal Dentin of Primary Anterior Teeth. J Dent (Tehran). 2018 Sep;15(5):300-308.Pubmed PMID: 30833976.
[38]. Farah RI, Aloraini AS, Al-Haj Ali SN. Fabrication of Custom Post-And-Core Using a Directly Fabricated Silicone Pattern and Digital Workflow. J Prosthodont. 2020 Aug;29(7):631-635.Pubmed PMID: 32567763.
[39]. Caglar I, Ates SM, Yesil Duymus Z. An In Vitro Evaluation of the Effect of Various Adhesives and Surface Treatments on Bond Strength of Resin Cement to Polyetheretherketone. J Prosthodont. 2019 Jan;28(1):e342-e349. Pubmed PMID: 29654646.
[40]. Shenoy VK, Prabhu MB. Computer-aided design/computer-aided manufacturing in dentistry–Future is present. J. Interdiscip. Dent. 2015 May 1;5(2):60.
[41]. Moustapha G, AlShwaimi E, Silwadi M, Ounsi H, Ferrari M, Salameh Z. Marginal and internal fit of CAD/CAM fiber post and cores. Int J Comput Dent. 2019;22(1):45-53.Pubmed PMID: 30848254.
[42]. Ender A, Mehl A. Full arch scans: conventional versus digital impressions- -an in-vitro study. Int J Comput Dent. 2011;14(1):11-21.Pubmed PMID: 21657122.
[43]. Falcăo Spina DR, da Costa RG, Correr GM, Rached RN. Scanning of root canal impression for the fabrication of a resin CAD-CAM-customized post-and-core. J Prosthet Dent. 2018 Aug;120(2):242-245.Pubmed PMID: 29475760.
[44]. Awad MA, Marghalani TY. Fabrication of a custom-made ceramic post and core using CAD-CAM technology. J Prosthet Dent. 2007 Aug 1;98(2):161- 2.
[45]. Eid RY, Koken S, Baba NZ, Ounsi H, Ferrari M, Salameh Z. Effect of Fabrication Technique and Thermal Cycling on the Bond Strength of CAD/ CAM Milled Custom Fit Anatomical Post and Cores: An In Vitro Study. J Prosthodont. 2019 Oct;28(8):898-905.Pubmed PMID: 31397947.