International Journal of Bioorganic Chemistry & Molecular Biology (IJBCMB)    IJBCMB-2332-2756-06-001e

Nuclear Resonance Vibrational Spectroscopy (NRVS), Nuclear Inelastic Scattering Spectroscopy (NISS), Nuclear Inelastic Absorption Spectroscopy (NIAS) and Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation



Alireza Heidari*

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA.

*Corresponding Author

Alireza Heidari,
Faculty of Chemistry, California South University,
14731 Comet St. Irvine, CA 92604, USA.
E-mail: Alireza.Heidari@calsu.us / Scholar.Researcher.Scientist@gmail.com;

Received: January 11, 2018; Published: February 07, 2018

Citation: Heidari A. Nuclear Resonance Vibrational Spectroscopy (NRVS), Nuclear Inelastic Scattering Spectroscopy (NISS), Nuclear Inelastic Absorption Spectroscopy (NIAS) and Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Int J Bioorg Chem Mol Biol. 2018;6(1e):1-5. DOI : dx.doi.org/10.19070/2332-2756-180008e

Copyright: Heidari A© 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.




In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Nuclear Resonance Vibrational Spectroscopy (NRVS), Nuclear Inelastic Scattering Spectroscopy (NISS), Nuclear Inelastic Absorption Spectroscopy (NIAS) and Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS). It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passing of time (Figures 1-4) [1-119].


Figure 1. Nuclear Resonance Vibrational Spectroscopy (NRVS) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passing of time [1-119].



Figure 2. Nuclear Inelastic Scattering Spectroscopy (NISS) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passing of time [1-119].



Figure 3. Nuclear Inelastic Absorption Spectroscopy (NIAS) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passing of time [1-119].



Figure 4. Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passing of time [1-119].


It can be concluded that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passing of time (Figures 1-4) [1-119].



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  96. Heidari A. Potency of Human Interferon β–1a and Human Interferon β–1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/ Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus. J Proteomics Enzymol 6:1. doi: 10.4172/2470-1289.1000e109.
  97. Heidari A. Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti-Cancer Nanodrugs Delivery across the Blood-Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation. J Pharm Pharmaceutics. 2017;4(2):1-5.
  98. Heidari A, Brown C. Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA)(Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti–Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems. Ann Adv Chem. 2017;1(2):061-9.
  99. Alireza Heidari, “Vibrational Spectroscopy of Nucleic Acids”, Wahid Ali Khan (Editor), “Basic Biochemistry”, Austin Publishing Group (APG)/Austin Publications LLC, ISBN: 978–0–9971499–2–0, Pages 1–18, Jersey City, New Jersey, USA, 2016.
  100. Heidari A. High-resolution simulations of human brain cancer translational nano drugs delivery treatment process under synchrotron radiation. J Transl Res. 2017;1(1):1-3.
  101. Heidari A. Investigation of Anti-Cancer Nano Drugs’ Effects’ Trend on Human Pancreas Cancer Cells and Tissues Prevention, Diagnosis and Treatment Process under Synchrotron and X-Ray Radiations with the Passage of Time Using Mathematica. Current Trends Anal Bioanal Chem.2017; 1 (1): 36-41.
  102. Alireza Heidari, “Pros and Cons Controversy on Molecular Imaging and Dynamics of Double–Standard DNA/RNA of Human Preserving Stem Cells–Binding Nano Molecules with Androgens/Anabolic Steroids (AAS) or Testosterone Derivatives through Tracking of Helium–4 Nucleus (Alpha Particle) Using Synchrotron Radiation”, Arch Biotechnol Biomed. 1 (1): 067–0100, 2017.
  103. Alireza Heidari . visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo Page 6 of 6 1 H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy and Self–Organizing Maps Under Synchrotron Radiation. SOJ Mater Sci Eng 2017.5(2): 1-6.
  104. Alireza Heidari, “Cavity Ring–Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Enliven: Challenges Cancer Detect Ther 4 (2): e001, 2017.
  105. Heidari A. Laser Spectroscopy, Laser-Induced Breakdown Spectroscopy and LaserInduced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Int J Hepatol Gastroenterol. 2017;3(4): 079-084.
  106. Heidari A. Time–Resolved Spectroscopy and Time–Stretch Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Enliven: Pharmacovigilance and Drug Safety. 2017;4(2):e001.
  107. Heidari A. Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation. Open J Anal Bioanal Chem.2017; 1(1): 021-026.
  108. Heidari A. Electron Phenomenological Spectroscopy, Electron Paramagnetic Resonance (EPR) Spectroscopy and Electron Spin Resonance (ESR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Austin J Anal Pharm Chem. 2017; 4(3): 1091.
  109. Heidari A. Therapeutic Nanomedicine Different High–Resolution Experimental Images and Computational Simulations for Human Brain Cancer Cells and Tissues Using Nanocarriers Deliver DNA/RNA to Brain Tumors under Synchrotron Radiation with the Passage of Time Using Mathematica and MATLAB. Madridge J Nano Tech. 2017 Nov 24;2(2):77-83. doi: 10.18689/mjnn.2017-113.
  110. Heidari A. A Consensus and Prospective Study on Restoring Cadmium Oxide (CdO) Nanoparticles Sensitivity in Recurrent Ovarian Cancer by Extending the Cadmium Oxide (CdO) Nanoparticles-Free Interval Using Synchrotron Radiation Therapy as Antibody–Drug Conjugate for the Treatment of Limited–Stage Small Cell Diverse Epithelial Cancers. Cancer Clin Res Rep. 2017;2. CCRR e101.
  111. Alireza Heidari . A Novel and Modern Experimental Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White Synchrotron Radiation. Cancer Sci Res Open Access. 2017; 4(2): 1-8. DOI: http://dx.doi.org/10.15226/csroa.2017.00137.
  112. Heidari A. Different High-Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti-Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X-Ray Radiations. J Med Oncol. 2017;1(1):1.
  113. Heidari A. Vibrational Decihertz (dHz), Centihertz (cHz), Millihertz (mHz), Microhertz (μHz), Nanohertz (nHz), Picohertz (pHz), Femtohertz (fHz), Attohertz (aHz), Zeptohertz (zHz) and Yoctohertz (yHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. International Journal of Biomedicine. 2017; 7(4), 335-340 DOI http://dx.doi.org/10.21103/Article7(4)_IA1 I. http://www.ijbm.org/articles/IJBM_7(4)_IA1.pdf
  114. Alireza Heidari. “Force Spectroscopy and Fluorescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”. EC Cancer. (2017); 2.5 239-246. https://www.ecronicon.com/ecca/pdf/ECCA-02-00036.pdf
  115. Alireza Heidari. Photoacoustic Spectroscopy, Photoemission Spectroscopy and Photothermal Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time Under Synchrotron Radiation. BAOJ Cancer Res Ther. 2017 3: 045. https://bioaccent.org/cancer-sciences/cancer-sciences45.pdf
  116. Heidari A, “J–Spectroscopy, Exchange Spectroscopy (EXSY), Nucle¬ar Overhauser Effect Spectroscopy (NOESY) and Total Correlation Spectroscopy (TOCSY) Comparative Study on Malignant and Benign HumanCancer Cells and Tissues under Synchrotron Radiation”, EMS Eng Sci J, 1 (2): 006–013, 2017.
  117. Alireza Heidari. Neutron Spin Echo Spectroscopy and Spin Noise Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Int J Biopharm Sci. 2018; 1:103. https://www.boffinaccess.com/open-accessjournals/ international-journal-of-biopharmaceutical-sciences/neutronspin-echo-spectroscopy-and-spin-noise-spectroscopy-comparative-studyijbs-1-103.php.
  118. Heidari A, “Vibrational Decahertz (daHz), Hectohertz (hHz), Kilohertz (kHz), Megahertz (MHz), Gigahertz (GHz), Terahertz (THz), Petahertz (PHz), Exahertz (EHz), Zettahertz (ZHz) and Yottahertz (YHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, Madridge J Anal Sci Instrum, 2 (1): 41–46, 2017.
  119. Alireza Heidari. Two-Dimensional Infrared Correlation Spectroscopy, Linear Two Dimensional Infrared Spectroscopy and Non-Linear Two-Dimensional Infrared Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. J Mater Sci Nanotechnol. 2018; 6(1): 101.

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